An article Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates WOS:000573134100001 published article about AMINATION; FUNCTIONALIZATION; INDOLINES; NITROGENATION in [Kim, Saegun; Jeoung, Daeun; Kim, Kunyoung; Lee, Suk Hun; Park, Min Seo; Ghosh, Prithwish; Mishra, Neeraj Kumar; Kim, In Su] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; [Lee, Seok Beom; Hong, Suckchang] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea in 2020, Cited 47. Application In Synthesis of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6
The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, andN-methoxyamides. Complete site-selectivity and functional group tolerance are observed. Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process.
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