What unique challenges do researchers face in 1-Phenylurea

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I found the field of Chemistry very interesting. Saw the article Enantioselective N-Acylation of Biginelli Dihydropyrimidines by Oxidative NHC Catalysis published in 2020.0. Application In Synthesis of 1-Phenylurea, Reprint Addresses Massi, A (corresponding author), Univ Ferrara, Dept Chem & Pharmaceut Sci, Via L Borsari 46, I-44121 Ferrara, Italy.. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea

The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the asymmetric variant produces pharmaceutically relevant N3-acylated products with good-to-moderate enantioselectivity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem