An article Preferential catabolism of the (S)-enantiomer of the herbicide napropamide mediated by the enantioselective amidohydrolase SnaH and the dioxygenase Snpd in Sphingobium sp. strain B2 WOS:000496407200001 published article about EFFICIENT GENERATION; AM1-BCC MODEL; PROTEIN; DEGRADATION; ENANTIOMERS in [Huang, Junwei; Chen, Dian; Jiang, Jiandong] Nanjing Agr Univ, Dept Microbiol, Coll Life Sci, Key Lab Microbiol Agr Environm,Minist Agr, Nanjing 210095, Jiangsu, Peoples R China; [Chen, Dian] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China in 2020.0, Cited 37.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Product Details of 64-10-8
The (R)- and (S)-enantiomers of the chiral herbicide napropamide (NAP) show different biological activities and ecotoxicities. These two enantiomers behave differently in the environment due to enantioselective catabolism by microorganisms. However, the molecular mechanisms underlying this enantioselective catabolism remain largely unknown. In this study, the genes (snaH and snpd) involved in the catabolism of NAP were cloned from Sphingobium sp. B2, which was capable of catabolizing both NAP enantiomers. Compared with (R)-NAP, (S)-NAP was much more rapidly transformed by the amidase SnaH, which initially cleaved the amide bonds of (S)/(R)-NAP to form (S)/(R)-2-(1-naphthalenyloxy)-propanoic acid [(S)/(R)-NP] and diethylamine. The alpha-ketoglutarate-dependent dioxygenase Snpd, showing strict stereoselectivity for (S)-NP, further transformed (S)-NP to 1-naphthol and pyruvate. Molecular docking and site-directed mutagenesis analyses revealed that when the (S)-enantiomers of NAP and NP occupied the active sites, the distance between the ligand molecule and the coordination atom was shorter than that when the (R)-enantiomers occupied the active sites, which facilitated formation of the transition state complex. This study enhances our understanding of the preferential catabolism of the (S)-enantiomer of NAP on the molecular level.
About 1-Phenylurea, If you have any questions, you can contact Huang, JW; Chen, D; Jiang, JD or concate me.. Product Details of 64-10-8
Reference:
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