Recently I am researching about ANDROGEN RECEPTOR; HISTONE H3; COACTIVATOR; CARM1; METHYLATION; DISCOVERY; TRANSCRIPTION; EXPRESSION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91853126]; Natural Science Foundation of China for Innovation Research GroupNational Natural Science Foundation of China (NSFC) [81821005]; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA12020371, XDA12020365]; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of China [2018ZX09711002-004-002, 2018ZX09711002-004-014]; Collaborative Innovation Cluster Project of Shanghai Municipal Commission of Health and Family Planning [2019CXJQ02]; Shanghai Talent Development Founds [201663]. Application In Synthesis of 1-Phenylurea. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Guo, ZH; Zhang, ZQ; Yang, H; Cao, DY; Xu, XW; Zheng, XN; Chen, DQ; Wang, Q; Li, YL; Li, J; Du, ZY; Wang, X; Chen, L; Ding, J; Shen, JK; Geng, MY; Huang, X; Xiong, B. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea
PRMT4 is a type I protein arginine methyltransferase and plays important roles in various cellular processes. Overexpression of PRMT4 has been found to be involved in several types of cancers. Selective and in vivo effective PRMT4 inhibitors are needed for demonstrating PRMT4 as a promising therapeutic target. On the basis of compound 6, a weak dual PRMT4/6 inhibitor, we constructed a tetrahydroisoquinoline scaffold through a cut-and-sew scaffold hopping strategy. The subsequent SAR optimization efforts employed structure-based approach led to the identification of a novel PRMT4 inhibitor 49. Compound 49 exhibited prominently high potency and selectivity, moderate pharmacokinetic profiles, and good antitumor efficacy in acute myeloid leukemia xenograft model via oral administration, thus demonstrating this compound as a useful pharmacological tool for further target validation and drug development in cancer therapy.
Welcome to talk about 64-10-8, If you have any questions, you can contact Guo, ZH; Zhang, ZQ; Yang, H; Cao, DY; Xu, XW; Zheng, XN; Chen, DQ; Wang, Q; Li, YL; Li, J; Du, ZY; Wang, X; Chen, L; Ding, J; Shen, JK; Geng, MY; Huang, X; Xiong, B or send Email.. Application In Synthesis of 1-Phenylurea
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem