Quality Control of 2-Aminobenzamide. Recently I am researching about BIOLOGICAL EVALUATION; AMPK; ADIPOGENESIS/LIPOGENESIS; DERIVATIVES; INHIBITORS; DESIGN; MICE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672265, 81930098, 81872732, 81703336]; Special Fund for Science and Technology Development in Guangdong Province [2016A020217004]; Science and Technology Program of Guangzhou [201704020104]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2017A030308003]; 111 ProjectMinistry of Education, China – 111 Project [B16047]; Ministry of Education of ChinaMinistry of Education, China [IRT-17R111]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [31610915]; Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y093]; Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Rao, Y; Xu, Z; Hu, YT; Li, C; Xu, YH; Song, QQ; Yu, H; Song, BB; Chen, SB; Li, QJ; Huang, SL; Tan, JH; Ou, TM; Wang, HG; Zhong, GP; Ye, JM; Huang, ZS. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide
Discovery of novel anti-obesity agents is a challenging and promising research area. Based on our previous works, we synthesized 40 novel beta-indoloquinazoline analogues by altering the skeleton and introducing preferential side chains, evaluated their lipid-lowering activity and summarized the structure-activity relationships. In combination with an evaluation of the lipid-lowering efficacies, AMP-dependent activated protein kinase (AMPK) activating ability and liver microsomal stability, compound 23 (named as IQZ23) was selected for further studies. IQZ23 exerted a high efficacy in decreasing the triglyceride level (EC50 = 0.033 mu M) in 3T3-L1 adipocytes. Mechanistic studies revealed the lipid-lowering activity of IQZ23 was dependent on the AMPK pathway by modulating ATP synthase activity. This activation was accompanied by mitochondrial biogenesis and oxidation capacity increased, and insulin sensitivity enhanced in pertinent cell models by various interventions. Correspondingly, IQZ23 (20 mg/kg, i.p.) treatment significantly reversed high fat and cholesterol diet (HFC)- induced body weight increases and accompanying clinical symptoms of obesity in mice but without indicative toxicity. These results indicate that IQZ23 could be a useful candidate for the treatment of obesity and related metabolic disorders. (c) 2020 Elsevier Masson SAS. All rights reserved.
About 2-Aminobenzamide, If you have any questions, you can contact Rao, Y; Xu, Z; Hu, YT; Li, C; Xu, YH; Song, QQ; Yu, H; Song, BB; Chen, SB; Li, QJ; Huang, SL; Tan, JH; Ou, TM; Wang, HG; Zhong, GP; Ye, JM; Huang, ZS or concate me.. Quality Control of 2-Aminobenzamide
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem