Recommanded Product: 88-68-6. I found the field of Chemistry very interesting. Saw the article Design and synthesis of novel sulphamide tethered quinazolinone hybrids as potential antitumor agents published in 2019, Reprint Addresses Nagarapu, L (corresponding author), CSIR Indian Inst Chem Technol, Fluoro Agrochem Div 2, Hyderabad 500007, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.
In an attempt to develop potential and selective antitumor agents, a series of novel sulphamide tethered quinazolinone hybrids were efficiently synthesized and evaluated for antitumor activity against four cancer cell lines such as HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and A549 (lung) in vitro. All the compounds (5a-j, 6a-g) exhibited significant anti-proliferative activity with GI(50) values ranging from 0.045 to 6.94 mu M, while compound 10c showed potent activity against all the cell lines (He La, MDA-MB-231, PANC-1 and A549) with GI(50) values ranging from 0.09 to 0.21 mu M. We have explored the binding mode and key active site interactions in HDAC8 and EHMT2 proteins. The docking results are complementary to the experimental results. (C) 2019 Elsevier B.V. All rights reserved.
Recommanded Product: 88-68-6. Welcome to talk about 88-68-6, If you have any questions, you can contact Venkatesh, R; Kasaboina, S; Jain, N; Janardhan, S; Holagunda, UD; Nagarapu, L or send Email.
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