I found the field of Chemistry very interesting. Saw the article Base and catalyst-free synthesis of nitrobenzodiazepines via a cascade N-nitroallylation-intramolecular aza-Michael addition involving o-phenylenediamines and nitroallylic acetates published in 2019. Formula: C7H8N2O, Reprint Addresses Namboothiri, INN (corresponding author), Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide
A [4+3] annulation of o-phenylenediamines with primary nitroallylic acetates affords nitrobenzodiazepines (NBDZs) in good to excellent yield. The reaction which proceeds in MeOH at room temperature in the absence of any base or catalyst involves a cascade S(N)2 N-nitroallylation-intramolecular aza-Michael addition sequence. In the case of mono-N-arylated o-phenylenediamines and o-aminobenzamides, the reaction stops at the S(N)2 stage affording nitroallylic amines. On the other hand, reaction of o-aminobenzamides with secondary nitroallylic acetates delivers S(N)2′ products. Formation of stable S(N)2 and S(N)2′ products provides insights into the reactivity of primary and secondary nitroallylic acetates and also the mechanism of formation of nitrobenzodiazepines. (C) 2019 Elsevier Ltd. All rights reserved.
Welcome to talk about 88-68-6, If you have any questions, you can contact Nair, DK; Sivanandan, ST; Kendrekar, P; Namboothiri, INN or send Email.. Recommanded Product: 2-Aminobenzamide
Reference:
Thiomorpholine – Wikipedia,
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