Recently I am researching about MULTICENTER PHASE-II; BREQUINAR SODIUM; IMMUNOSUPPRESSIVE DRUG; PLASMODIUM-FALCIPARUM; PYRIMIDINE SYNTHESIS; DHODH; VIDOFLUDIMUS; LEFLUNOMIDE; DISCOVERY; BLOCKADE, Saw an article supported by the National Key Research and Development Program (China) [2017YFD0200505, 2016YFA0502304]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81825020, 81803437]; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program (China) [2018ZX09711002]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Shanghai Foundation of Science and Technology [15431902100]; Shanghai Sailing Program (China) [18YF1405100]; National Program for Special Supports of Eminent Professionals; National Program for Support of Top-Notch Young Professionals, China. Published in INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES in BEIJING ,Authors: Zeng, FX; Li, SL; Yang, GT; Luo, YT; Qi, TT; Liang, YF; Yang, TY; Zhang, LT; Wang, R; Zhu, LL; Li, HL; Xu, XY. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Name: 2-Aminobenzamide
Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structure-activity relationship (SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar range. Further structure optimization revealed that an acrylamide with small hydrophobic groups (Me, Cl or Br) at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53.55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic (PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Name: 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem