Application In Synthesis of 1-Methyl-4-nitro-1H-imidazol-5-amine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Methyl-4-nitro-1H-imidazol-5-amine, is researched, Molecular C4H6N4O2, CAS is 4531-54-8, about A catalyst and additive-free three-component reaction of highly electrophilic azides with cyclic ketones and cycloaliphatic amines. Synthesis of novel N-heteroaryl amidines. Author is Efimov, Ilya; Beliaev, Nikolai; Beryozkina, Tetyana; Slepukhin, Pavel; Bakulev, Vasiliy.
Highly electrophilic 5-azido-1-methyl-4-nitro-1H-imidazole and sulfonyl azides were demonstrated to react with alicyclic amines and cyclic ketones in the absence of any catalyst or additive to afford novel N-(4-nitroimidazol-5-yl)- or N-sulfonylamidines resp. Based on single crystal X-ray anal., a revision of the previously reported data of Gao and co-workers on the direction of the reaction of sulfonyl azides with endocyclic enamines was made. The reaction of 2,6-diazidopyridine with an enamine, 4-(cyclohex-1-en-1-yl)morpholine, proceeded with cyclization of the azide moiety onto the pyridine C=N bond to form an amidine bearing the tetrazolo[1,5-a]pyridine fragment.
There is still a lot of research devoted to this compound(SMILES：NC1=C([N+]([O-])=O)N=CN1C)Application In Synthesis of 1-Methyl-4-nitro-1H-imidazol-5-amine, and with the development of science, more effects of this compound(4531-54-8) can be discovered.
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem