Category: 125464-42-8

Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. In an article, author is Lanoix, J. -P., once mentioned the application of 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formula is C9H12ClNO3S, molecular weight is 249.7145, MDL number is MFCD00216817, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 125464-42-8.

In the context of increasing drug resistance among Mycobacterium tuberculosis (Mtb) strains, new, potent and well tolerated drugs are urgently needed. Bedaquiline has obtained accelerated approval, but additional novel agents are needed to enable effective combination chemotherapy of extensively drug-resistant tuberculosis (TB). Linezolid, the first and only marketed oxazolidinone antibiotic, has shown certain activity against Mtb. However, serious safety concerns related to long-term administration have limited its utility for TB treatment. Sutezolid (formerly PNU-100480) is a thiomorpholine analogue of linezolid with greater potency in several experimental TB models and the potential for a superior safety profile. This article reviews available preclinical and clinical data regarding the pharmacokinetics, safety and efficacy of sutezolid and presents the case for its further development for the treatment of TB.

Related Products of 125464-42-8, You can get involved in discussing the latest developments in this exciting area about 125464-42-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards., Product Details of 125464-42-8, 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formula is C9H12ClNO3S, belongs to thiomorpholine compound. In a document, author is Demirci, Serpil, introduce the new discover.

Thiomorpholine was converted to the corresponding 1,3,4-oxadiazole (4), arylidenehydrazide (5a-e), and 1,2,4-triazole (7a and, 7b) derivatives via the formation of hydrazide (3). Compounds 4 and 7 were next converted to the corresponding Mannich bases containing piperidin, beta-lactam, fluoroquinolone, piperazine, or morpholine core. Conventional and microwave-assisted methods were used for all syntheses. The effect of acid catalyst on Mannich reactions was also investigated. All the newly synthesized compounds were screened for their antimicrobial, antiglucosidase, antilipase, anti-urease, and antioxidant activities. Most exhibited good-moderate antibacterial and/or antifungal activity. Docking of some of the synthesized compounds into the active sites of lipase, alpha-glucosidase, and urease was carried out in order to predict the binding affinities and noncovalent interactions stabilizing the enzyme-ligand complexes. Docking results complemented well the experimental results on inhibitory effects of compounds. Higher binding affinities were observed for active compounds in contrary to inactive ones.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 125464-42-8, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/125464-42-8.html.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 125464-42-8 in 2021. Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Basoglu, Serap, introducing its new discovery. Recommanded Product: 125464-42-8.

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 125464-42-8, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/125464-42-8.html.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 125464-42-8 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Prabhakar, V., introducing its new discovery. Related Products of 125464-42-8.

Heterocyclic Chemistry comprises at least half of all organic chemistry research worldwide. Quinazoline and its derivatives constitute an important class of heterocyclic compounds. The chemistry of quinazoline compounds has more than centuries old history, however the intense search for biologically active substances in quinazoline series began only in the last few cascades. In this present communication an attempt is made to cover the medicinally active compounds, along with the recent synthesis, which were reported to possess antimicrobial and antifungal activity.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 125464-42-8. Synthetic Route of 125464-42-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 125464-42-8 in 2021. Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Prabhakar, V., introducing its new discovery. Related Products of 125464-42-8.

Heterocyclic Chemistry comprises at least half of all organic chemistry research worldwide. Quinazoline and its derivatives constitute an important class of heterocyclic compounds. The chemistry of quinazoline compounds has more than centuries old history, however the intense search for biologically active substances in quinazoline series began only in the last few cascades. In this present communication an attempt is made to cover the medicinally active compounds, along with the recent synthesis, which were reported to possess antimicrobial and antifungal activity.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 125464-42-8. Synthetic Route of 125464-42-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Kang, Gihaeng, introducing its new discovery. Related Products of 125464-42-8.

In the title compound, C7H13NOS2, the thiomorpholine ring adopts a chair conformation and the bond-angle sum at the N atom is 360 degrees. The dihedral angle between the amide group and the thiomorpholine ring (all atoms) is 36.48 (12)degrees. In the crystal, C-H center dot center dot center dot O and C-H center dot center dot center dot S hydrogen bonds link adjacent molecules, forming two-dimensional networks extending parellel to the (011) plane.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 125464-42-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Lanoix, J. -P., introducing its new discovery. Application of 125464-42-8.

In the context of increasing drug resistance among Mycobacterium tuberculosis (Mtb) strains, new, potent and well tolerated drugs are urgently needed. Bedaquiline has obtained accelerated approval, but additional novel agents are needed to enable effective combination chemotherapy of extensively drug-resistant tuberculosis (TB). Linezolid, the first and only marketed oxazolidinone antibiotic, has shown certain activity against Mtb. However, serious safety concerns related to long-term administration have limited its utility for TB treatment. Sutezolid (formerly PNU-100480) is a thiomorpholine analogue of linezolid with greater potency in several experimental TB models and the potential for a superior safety profile. This article reviews available preclinical and clinical data regarding the pharmacokinetics, safety and efficacy of sutezolid and presents the case for its further development for the treatment of TB.

Application of 125464-42-8, You can get involved in discussing the latest developments in this exciting area about 125464-42-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 125464-42-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Demirci, Serpil, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/125464-42-8.html.

Thiomorpholine was converted to the corresponding 1,3,4-oxadiazole (4), arylidenehydrazide (5a-e), and 1,2,4-triazole (7a and, 7b) derivatives via the formation of hydrazide (3). Compounds 4 and 7 were next converted to the corresponding Mannich bases containing piperidin, beta-lactam, fluoroquinolone, piperazine, or morpholine core. Conventional and microwave-assisted methods were used for all syntheses. The effect of acid catalyst on Mannich reactions was also investigated. All the newly synthesized compounds were screened for their antimicrobial, antiglucosidase, antilipase, anti-urease, and antioxidant activities. Most exhibited good-moderate antibacterial and/or antifungal activity. Docking of some of the synthesized compounds into the active sites of lipase, alpha-glucosidase, and urease was carried out in order to predict the binding affinities and noncovalent interactions stabilizing the enzyme-ligand complexes. Docking results complemented well the experimental results on inhibitory effects of compounds. Higher binding affinities were observed for active compounds in contrary to inactive ones.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 125464-42-8, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/125464-42-8.html.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 125464-42-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, molecular formurla is C9H12ClNO3S. In a document, author is Prabhakar, V., introducing its new discovery. Application of 125464-42-8.

Heterocyclic Chemistry comprises at least half of all organic chemistry research worldwide. Quinazoline and its derivatives constitute an important class of heterocyclic compounds. The chemistry of quinazoline compounds has more than centuries old history, however the intense search for biologically active substances in quinazoline series began only in the last few cascades. In this present communication an attempt is made to cover the medicinally active compounds, along with the recent synthesis, which were reported to possess antimicrobial and antifungal activity.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. You can also check out more blogs about 125464-42-8. Application of 125464-42-8.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: https://www.ambeed.com/products/125464-42-8.html, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 125464-42-8, Name is 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid, SMILES is O=S(CC(C1=CC=C(Cl)C=C1)CN)(O)=O, molecular formula is C9H12ClNO3S, belongs to thiomorpholine compound. In an article, author is Basoglu, Serap, introduce new discover of the category.

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 125464-42-8, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/125464-42-8.html.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem