Category: 321-23-3

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In an article, author is Basoglu, Serap, once mentioned the application of 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, molecular weight is 220, MDL number is MFCD01930221, category is thiomorpholine. Now introduce a scientific discovery about this category, Application of 321-23-3.

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Name: 4-Bromo-2-fluoronitrobenzene, 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, belongs to thiomorpholine compound. In a document, author is Ghorab, M. M., introduce the new discover.

Interaction of dapson [bis(4-aminophenyl)sulfone] 1 with [bis-(methylsulfonyl) methylidine]malononitrile 2 yielded the corresponding dicyano derivative 3, which was reacted with acetic anhydride, succinic anhydride, 4-chlorobenzaldehyde, phenyl isothiocyanate to give the corresponding acetamide 4, succinamic acid 5, pyrrolidine 6, Shiff base 7 and thiourea 8, respectively. Treatment of 3 with chloroacetyl chloride afforded the aminoacetyl chloride derivative 9. Further, the interaction of compound 9 with thioglycolic acid, malononitrile, ethyl glycinate hydrochloride, and/or potassium thiocyanate furnished compounds 10-15, respectively. The structural characterization of the prepared compounds was based on microanalytical and spectroscopic analyses. Some of the prepared compounds were tested for their antimicrobial and antitumor activities. Compounds 9 and 12 showed promising antitumor activity compared with Doxorubicin as positive control.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Synthetic Route of 321-23-3, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects.321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, SMILES is BrC1=CC(=C(C=C1)[N+](=O)[O-])F, belongs to thiomorpholine compound. In a article, author is Kang, Gihaeng, introduce new discover of the category.

In the title compound, C7H13NOS2, the thiomorpholine ring adopts a chair conformation and the bond-angle sum at the N atom is 360 degrees. The dihedral angle between the amide group and the thiomorpholine ring (all atoms) is 36.48 (12)degrees. In the crystal, C-H center dot center dot center dot O and C-H center dot center dot center dot S hydrogen bonds link adjacent molecules, forming two-dimensional networks extending parellel to the (011) plane.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Reference of 321-23-3, 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, belongs to thiomorpholine compound. In a document, author is Lanoix, J. -P., introduce the new discover.

In the context of increasing drug resistance among Mycobacterium tuberculosis (Mtb) strains, new, potent and well tolerated drugs are urgently needed. Bedaquiline has obtained accelerated approval, but additional novel agents are needed to enable effective combination chemotherapy of extensively drug-resistant tuberculosis (TB). Linezolid, the first and only marketed oxazolidinone antibiotic, has shown certain activity against Mtb. However, serious safety concerns related to long-term administration have limited its utility for TB treatment. Sutezolid (formerly PNU-100480) is a thiomorpholine analogue of linezolid with greater potency in several experimental TB models and the potential for a superior safety profile. This article reviews available preclinical and clinical data regarding the pharmacokinetics, safety and efficacy of sutezolid and presents the case for its further development for the treatment of TB.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves., Application of 321-23-3, 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, belongs to thiomorpholine compound. In a document, author is Graton, J, introduce the new discover.

Using 4-fluorophenol as a reference hydrogen-bond donor, equilibrium constants K for the formation of 1 : 1 hydrogen-bonded complexes have been obtained by FTIR spectrometry for 33 secondary amines in CCl4 and/or C2Cl4 at 298 K. A spectroscopic scale of hydrogen-bond basicity is constructed from the IR frequency shift Av(OH) of methanol hydrogen-bonded to secondary amines. The comparison of the pK(HB) (log K), Deltav(OH), and pK(a) scales points to the sensitivity of pK(HB) to steric effects, and of Deltav(OH) to the p character of the nitrogen lone pair. The pKHB scale of secondary amines extends from 2.59 for pyrrolidine to -0.45 for (Me3Si)(2)NH. The main effects explaining the pK(HB) variations are (i) the opposite polarizability and steric effects in alkylamines, (ii) field-inductive effects (e.g N drop CCH2NHMe), (iii) intramolecular hydrogen bonding, e.g. in (MeOCH2CH2)(2)NH, and (iv) the ring size giving the order: pyrrolidine = azetidine > piperidine > 2-methylaziridine > azepane. IR spectra show the attachment of 4-fluorophenol to the nitrile nitrogen of N drop CCH2NHMe and N drop CCH2CH2NHMe, to the oxygen of morpholine and (MeOCH2CH2)(2)NH, and to the sulfur of thiomorpholine and thiazolidine, in addition to attachment to the amino nitrogen. The correlation of pK(HB) with the minimum electrostatic potential on the nitrogen lone pair is used for unravelling the basicity of each nitrogen of 1-methyl-1,4-diazepane.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Kang, Gihaeng, once mentioned the application of 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, molecular weight is 220, MDL number is MFCD01930221, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 321-23-3.

In the title compound, C7H13NOS2, the thiomorpholine ring adopts a chair conformation and the bond-angle sum at the N atom is 360 degrees. The dihedral angle between the amide group and the thiomorpholine ring (all atoms) is 36.48 (12)degrees. In the crystal, C-H center dot center dot center dot O and C-H center dot center dot center dot S hydrogen bonds link adjacent molecules, forming two-dimensional networks extending parellel to the (011) plane.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Graton, J, once mentioned the application of 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formula is C6H3BrFNO2, molecular weight is 220, MDL number is MFCD01930221, category is thiomorpholine. Now introduce a scientific discovery about this category, Electric Literature of 321-23-3.

Using 4-fluorophenol as a reference hydrogen-bond donor, equilibrium constants K for the formation of 1 : 1 hydrogen-bonded complexes have been obtained by FTIR spectrometry for 33 secondary amines in CCl4 and/or C2Cl4 at 298 K. A spectroscopic scale of hydrogen-bond basicity is constructed from the IR frequency shift Av(OH) of methanol hydrogen-bonded to secondary amines. The comparison of the pK(HB) (log K), Deltav(OH), and pK(a) scales points to the sensitivity of pK(HB) to steric effects, and of Deltav(OH) to the p character of the nitrogen lone pair. The pKHB scale of secondary amines extends from 2.59 for pyrrolidine to -0.45 for (Me3Si)(2)NH. The main effects explaining the pK(HB) variations are (i) the opposite polarizability and steric effects in alkylamines, (ii) field-inductive effects (e.g N drop CCH2NHMe), (iii) intramolecular hydrogen bonding, e.g. in (MeOCH2CH2)(2)NH, and (iv) the ring size giving the order: pyrrolidine = azetidine > piperidine > 2-methylaziridine > azepane. IR spectra show the attachment of 4-fluorophenol to the nitrile nitrogen of N drop CCH2NHMe and N drop CCH2CH2NHMe, to the oxygen of morpholine and (MeOCH2CH2)(2)NH, and to the sulfur of thiomorpholine and thiazolidine, in addition to attachment to the amino nitrogen. The correlation of pK(HB) with the minimum electrostatic potential on the nitrogen lone pair is used for unravelling the basicity of each nitrogen of 1-methyl-1,4-diazepane.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 4-Bromo-2-fluoronitrobenzene, New discoveries in chemical research and development in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, SMILES is BrC1=CC(=C(C=C1)[N+](=O)[O-])F, molecular formula is C6H3BrFNO2, belongs to thiomorpholine compound. In an article, author is Ghorab, M. M., introduce new discover of the category.

Interaction of dapson [bis(4-aminophenyl)sulfone] 1 with [bis-(methylsulfonyl) methylidine]malononitrile 2 yielded the corresponding dicyano derivative 3, which was reacted with acetic anhydride, succinic anhydride, 4-chlorobenzaldehyde, phenyl isothiocyanate to give the corresponding acetamide 4, succinamic acid 5, pyrrolidine 6, Shiff base 7 and thiourea 8, respectively. Treatment of 3 with chloroacetyl chloride afforded the aminoacetyl chloride derivative 9. Further, the interaction of compound 9 with thioglycolic acid, malononitrile, ethyl glycinate hydrochloride, and/or potassium thiocyanate furnished compounds 10-15, respectively. The structural characterization of the prepared compounds was based on microanalytical and spectroscopic analyses. Some of the prepared compounds were tested for their antimicrobial and antitumor activities. Compounds 9 and 12 showed promising antitumor activity compared with Doxorubicin as positive control.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

New research progress on 321-23-3 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, molecular formurla is C6H3BrFNO2. In a document, author is Lanoix, J. -P., introducing its new discovery. Electric Literature of 321-23-3.

In the context of increasing drug resistance among Mycobacterium tuberculosis (Mtb) strains, new, potent and well tolerated drugs are urgently needed. Bedaquiline has obtained accelerated approval, but additional novel agents are needed to enable effective combination chemotherapy of extensively drug-resistant tuberculosis (TB). Linezolid, the first and only marketed oxazolidinone antibiotic, has shown certain activity against Mtb. However, serious safety concerns related to long-term administration have limited its utility for TB treatment. Sutezolid (formerly PNU-100480) is a thiomorpholine analogue of linezolid with greater potency in several experimental TB models and the potential for a superior safety profile. This article reviews available preclinical and clinical data regarding the pharmacokinetics, safety and efficacy of sutezolid and presents the case for its further development for the treatment of TB.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 321-23-3. Electric Literature of 321-23-3.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Synthetic Route of 321-23-3, Chemical Research Letters, May 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 321-23-3, Name is 4-Bromo-2-fluoronitrobenzene, SMILES is BrC1=CC(=C(C=C1)[N+](=O)[O-])F, belongs to thiomorpholine compound. In a article, author is Basoglu, Serap, introduce new discover of the category.

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem