Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 531-91-9, 531-91-9, Name is N4,N4′-Diphenyl-[1,1′-biphenyl]-4,4′-diamine, SMILES is C1(C2=CC=C(NC3=CC=CC=C3)C=C2)=CC=C(NC4=CC=CC=C4)C=C1, belongs to thiomorpholine compound. In a document, author is Tooulia, Kyriaki-Konstantina, introduce the new discover.
Thiomorpholine Derivatives with Hypolipidemic and Antioxidant Activity
A number of thiomorpholine derivatives that are structurally similar to some substituted morpholines possessing antioxidant and hypocholesterolemic activity were synthesized. The new compounds incorporate an antioxidant moiety as the thiomorpholine N-substituent. The derivatives were found to inhibit the ferrous/ascorbate-induced lipid peroxidation of microsomal membrane lipids, with IC50 values as low as 7.5 mu M. In addition, these compounds demonstrate hypocholesterolemic and hypolipidemic action. The most active compound (5) decreases the triglyceride, total cholesterol, and low-density lipoprotein levels in the plasma of Triton WR-1339-induced hyperlipidemic rats, by 80, 78, and 76%, respectively, at 56mmol/kg (i.p.). They may also act as squalene synthase inhibitors. The above results indicate that the new molecules may be useful as leads for the design of novel compounds as potentially antiatherogenic factors.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 531-91-9 is helpful to your research. Product Details of 531-91-9.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem