Category: 81-64-1

New Advances in Chemical Research, May 2021. The prevalence of solvent effects has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. In an article, author is Mohamed, Tarek, once mentioned the application of 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4, molecular weight is 240.21, MDL number is MFCD00001209, category is thiomorpholine. Now introduce a scientific discovery about this category, Synthetic Route of 81-64-1.

A group of 2,4-disubstituted pyrimidine derivatives (7a-e, 8a-e and 9a-d) that possess a variety of C-2 aliphatic five-and six-membered heterocycloalkyl ring in conjunction with a C-4 arylalkylamino substituent were designed, synthesized and evaluated as cholinesterase (ChE) inhibitors. The steric and electronic properties at C-2 and C-4 positions of the pyrimidine ring were varied to investigate their effect on ChE inhibitory potency and selectivity. The structure-activity relationship (SAR) studies identified N-benzyl-2-thiomorpholinopyrimidin-4-amine (7c) as the most potent cholinesterase inhibitor (ChEI) with an IC50 = 0.33 mu M (acetylcholinesterase, AChE) and 2.30 mu M (butyrylcholinesterase, BuChE). The molecular modeling studies indicate that within the AChE active site, the C-2 thiomorpholine substituent was oriented toward the cationic active site region (Trp84 and Phe330) whereas within the BuChE active site, it was oriented toward a hydrophobic region closer to the active site gorge entrance (Ala277). Accordingly, steric and electronic properties at the C-2 position of the pyrimidine ring play a critical role in ChE inhibition. (C) 2010 Elsevier Ltd. All rights reserved.

Synthetic Route of 81-64-1, You can get involved in discussing the latest developments in this exciting area about 81-64-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Babu, K. Sudhakar, once mentioned the application of 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4, molecular weight is 240.21, MDL number is MFCD00001209, category is thiomorpholine. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/81-64-1.html.

Objective: In search of new potential antimicrobial agents, the aim of the present study was to synthesize the series of Quinazoline analogs by a simple and accessible approach and evaluate for their antimicrobial activity. Methods: Synthetic methodology involves the reaction of an anthranilic acid (1) with urea toget -2,4 di hydroxyl quinazoline (2) intermediate, which were further treated with POCl3 to get 2,4 di chloro quinazoline (3) derivative. Next 2,4 di chloro quinazoline (3) reacts with hydrazine hydrate in methanol for 4 hrs to get compounds, which further reacts with different carboxylic acids in POCl3 a series of novel fused 1,2,4 triazole derivatives, which were reacts with 4-thiomorpholinoaniline (7) in acetic acid to give target compounds (8a-k) in good yields. Results: The structures of the synthesized compounds were provided by spectral analysis, and the Synthesised compounds were tested for their antimicrobial activity against different fungi and bacteria species in vitro. Conclusion: The results of the study reveal that the new compounds possess promising antimicrobial activities.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. I hope my blog about 81-64-1 is helpful to your research. COA of Formula: https://www.ambeed.com/products/81-64-1.html.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Synthetic Route of 81-64-1, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, SMILES is O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O, molecular formula is C14H8O4, belongs to thiomorpholine compound. In a article, author is Mohamed, Tarek, introduce new discover of the category.

Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors

A group of 2,4-disubstituted pyrimidine derivatives (7a-e, 8a-e and 9a-d) that possess a variety of C-2 aliphatic five-and six-membered heterocycloalkyl ring in conjunction with a C-4 arylalkylamino substituent were designed, synthesized and evaluated as cholinesterase (ChE) inhibitors. The steric and electronic properties at C-2 and C-4 positions of the pyrimidine ring were varied to investigate their effect on ChE inhibitory potency and selectivity. The structure-activity relationship (SAR) studies identified N-benzyl-2-thiomorpholinopyrimidin-4-amine (7c) as the most potent cholinesterase inhibitor (ChEI) with an IC50 = 0.33 mu M (acetylcholinesterase, AChE) and 2.30 mu M (butyrylcholinesterase, BuChE). The molecular modeling studies indicate that within the AChE active site, the C-2 thiomorpholine substituent was oriented toward the cationic active site region (Trp84 and Phe330) whereas within the BuChE active site, it was oriented toward a hydrophobic region closer to the active site gorge entrance (Ala277). Accordingly, steric and electronic properties at the C-2 position of the pyrimidine ring play a critical role in ChE inhibition. (C) 2010 Elsevier Ltd. All rights reserved.

Synthetic Route of 81-64-1, The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic. I hope my blog about 81-64-1 is helpful to your research.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. In homogeneous catalysis, catalysts are in the same phase as the reactants. 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formurla is C14H8O4. In a document, author is Tanokashira, Natsuki, introducing its new discovery. Application In Synthesis of 1,4-Dihydroxyanthracene-9,10-dione.

Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani

We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with 1050 values in the range of 0.13-2.0 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

Application In Synthesis of 1,4-Dihydroxyanthracene-9,10-dione, In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts.you can also check out more blogs about 81-64-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Hamama, WS, once mentioned the application of 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4, molecular weight is 240.21, MDL number is MFCD00001209, category is thiomorpholine. Now introduce a scientific discovery about this category, COA of Formula: C14H8O4.

Behaviour of 2,3-dihydro-1H-benzo[d]imidazole-2-thione towards amines under Mannich-type condition

2,3-Dihydro-1H-benzo[d]imidazole-2-thione (1) was subjected to a Mannich reaction with either dimethylamine, urotropine, morpholine, thiomorpholine, (+/-) 3,3,5 trimethylhexahydroazepine, piperazine or p-bromoaniline and formalin in different molar ratios to afford the Mannich bases. The reactivity of the Mannich base 5a towards indole was also investigated. In addition the condensation of hydroxymethyl derivative 10 with morpholine, benzimidazole, p-bromoaniline, tryptamine and aminiothiazole was achieved.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Welcome to check out more blogs about 81-64-1, in my other articles. COA of Formula: C14H8O4.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , SDS of cas: 81-64-1, 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4, belongs to thiomorpholine compound. In a document, author is Kim, Yong-Hak, introduce the new discover.

Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp strain THO100 isolated from a morpholine-containing culture of activated sewage sludge

Mycobacterium sp. strain THO100 was isolated from a morpholine-containing culture of activated sewage sludge. This strain was able to utilize pyrrolidine, morpholine, piperidine, piperazine, and 1,2,3,6-tetrahydropyridine as the sole sources of carbon, nitrogen, and energy. The degradation pathway of pyrrolidine as the best substrate for cellular growth was proposed based on the assays of substrate-induced cytochrome P450 and constitutive enzyme activities toward 4-aminobutyric acid (GABA) and succinic semialdehyde (SSA). Its 16S ribosomal RNA gene sequence (16S rDNA) was identical to that of Mycobacterium tokaiense ATCC 27282(T)p. The morABC genes responsible for alicyclic amine degradation were nearly identical among different species of Mycobacteria. Remarkably, repetitive sequences at the intergenic spacer (IGS) region between morC and orf1′ were detected by comparison of the nearly identical mor gene cluster regions. Considering the strain activity for alicyclic amine degradation, the deleted 65-bp DNA segment did not significantly alter the open reading frames, and the expression and functions of the P450(mor) system remained unaltered. In addition, we found a spontaneous deletion of P450(mor) from another strain HE5 containing the archetypal mor gene cluster, which indicated a possible occurrence of DNA recombination to rearrange the DNA.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.If you’re interested in learning more about 81-64-1. The above is the message from the blog manager. SDS of cas: 81-64-1.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C14H8O4, 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, SMILES is O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O, belongs to thiomorpholine compound. In a document, author is Tanokashira, Natsuki, introduce the new discover.

Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani

We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with 1050 values in the range of 0.13-2.0 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 81-64-1. Formula: C14H8O4.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4, belongs to thiomorpholine compound. In a document, author is Hamama, WS, introduce the new discover, Recommanded Product: 1,4-Dihydroxyanthracene-9,10-dione.

Behaviour of 2,3-dihydro-1H-benzo[d]imidazole-2-thione towards amines under Mannich-type condition

2,3-Dihydro-1H-benzo[d]imidazole-2-thione (1) was subjected to a Mannich reaction with either dimethylamine, urotropine, morpholine, thiomorpholine, (+/-) 3,3,5 trimethylhexahydroazepine, piperazine or p-bromoaniline and formalin in different molar ratios to afford the Mannich bases. The reactivity of the Mannich base 5a towards indole was also investigated. In addition the condensation of hydroxymethyl derivative 10 with morpholine, benzimidazole, p-bromoaniline, tryptamine and aminiothiazole was achieved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 81-64-1. Recommanded Product: 1,4-Dihydroxyanthracene-9,10-dione.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4. In an article, author is Babu, K. Sudhakar,once mentioned of 81-64-1, HPLC of Formula: C14H8O4.

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINAZOLINE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS

Objective: In search of new potential antimicrobial agents, the aim of the present study was to synthesize the series of Quinazoline analogs by a simple and accessible approach and evaluate for their antimicrobial activity. Methods: Synthetic methodology involves the reaction of an anthranilic acid (1) with urea toget -2,4 di hydroxyl quinazoline (2) intermediate, which were further treated with POCl3 to get 2,4 di chloro quinazoline (3) derivative. Next 2,4 di chloro quinazoline (3) reacts with hydrazine hydrate in methanol for 4 hrs to get compounds, which further reacts with different carboxylic acids in POCl3 a series of novel fused 1,2,4 triazole derivatives, which were reacts with 4-thiomorpholinoaniline (7) in acetic acid to give target compounds (8a-k) in good yields. Results: The structures of the synthesized compounds were provided by spectral analysis, and the Synthesised compounds were tested for their antimicrobial activity against different fungi and bacteria species in vitro. Conclusion: The results of the study reveal that the new compounds possess promising antimicrobial activities.

Interested yet? Keep reading other articles of 81-64-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C14H8O4.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In an article, author is Kim, Yong-Hak, once mentioned the application of 81-64-1, Name is 1,4-Dihydroxyanthracene-9,10-dione, molecular formula is C14H8O4, molecular weight is 240.21, MDL number is MFCD00001209, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: 1,4-Dihydroxyanthracene-9,10-dione.

Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp strain THO100 isolated from a morpholine-containing culture of activated sewage sludge

Mycobacterium sp. strain THO100 was isolated from a morpholine-containing culture of activated sewage sludge. This strain was able to utilize pyrrolidine, morpholine, piperidine, piperazine, and 1,2,3,6-tetrahydropyridine as the sole sources of carbon, nitrogen, and energy. The degradation pathway of pyrrolidine as the best substrate for cellular growth was proposed based on the assays of substrate-induced cytochrome P450 and constitutive enzyme activities toward 4-aminobutyric acid (GABA) and succinic semialdehyde (SSA). Its 16S ribosomal RNA gene sequence (16S rDNA) was identical to that of Mycobacterium tokaiense ATCC 27282(T)p. The morABC genes responsible for alicyclic amine degradation were nearly identical among different species of Mycobacteria. Remarkably, repetitive sequences at the intergenic spacer (IGS) region between morC and orf1′ were detected by comparison of the nearly identical mor gene cluster regions. Considering the strain activity for alicyclic amine degradation, the deleted 65-bp DNA segment did not significantly alter the open reading frames, and the expression and functions of the P450(mor) system remained unaltered. In addition, we found a spontaneous deletion of P450(mor) from another strain HE5 containing the archetypal mor gene cluster, which indicated a possible occurrence of DNA recombination to rearrange the DNA.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 81-64-1, Recommanded Product: 1,4-Dihydroxyanthracene-9,10-dione.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem