New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is CECCHETTI, V, once mentioned the application of 86-48-6, Name is 1-Hydroxy-2-naphthoic acid, molecular formula is C11H8O3, molecular weight is 188.1794, MDL number is MFCD00003960, category is thiomorpholine. Now introduce a scientific discovery about this category, Application of 86-48-6.
A series of quinolone- and 1,8-naphthyridone-3-carboxylic acids, designed by previous QSAR studies and characterized by an amino group at the C-6 position instead of the usual fluorine atom, were synthesized for the first time and evaluated for in vitro antibacterial activity. All of the synthesized compounds maintain good activity against Gram-negative bacteria (Pseudomonas aeruginosa excluded), and those compounds having a thiomorpholine group as the C-7 substituent also have good activity against Gram-positive bacteria. Some aspects of structure-activity relationships associated with the C-1, C-5, C-7, and C-8 substituents are also discussed. Derivatives 18g and 38g displayed the best activity with geometric mean MICs of 0.45 and 0.66-0.76 mu g/mL against Gram-negative and Gram-positive bacteria, respectively. This antimicrobial activity reflects their ability to inhibit bacterial DNA-gyrase. The results of this study show that, while the C-6 fluorine is still the preferred substituent, good activity can still be obtained by replacing it with an amino group.
Application of 86-48-6, In the meantime we’ve collected together some recent articles in this area about 86-48-6. to whet your appetite. Happy reading!
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem