Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Nucleophilic substitution reactions of 1-methyl-4,5-dinitroimidazole with aqueous ammonia or sodium azide》. Authors are Lian, Peng-Bao; Guo, Xiao-Jie; Wang, Jian-Long; Chen, Li-Zhen; Shen, Fan-Fan.The article about the compound:1-Methyl-4-nitro-1H-imidazol-5-aminecas:4531-54-8,SMILESS:NC1=C([N+]([O-])=O)N=CN1C).Name: 1-Methyl-4-nitro-1H-imidazol-5-amine. Through the article, more information about this compound (cas:4531-54-8) is conveyed.

In this work, 5-amino-1-methyl-4-nitroimidazole was synthesized by amination reaction of 1-methyl-4,5-dinitroimidazole with aqueous ammonia in 95% yield. Meanwhile, one of its isomers, 4-amino-1-methyl-5-nitroimidazole as byproduct was obtained from the filtrate. Furthermore, nucleophilic substitution reaction of 1-methyl-4,5-dinitroimidazole with sodium azide gave 5-azido-1-methyl-4-nitroimidazole in 98% yield. The three compounds were characterized by IR, 1H and 13C NMR spectra, m.ps., and elemental anal. The structure of 4-amino-1-methyl-5-nitroimidazole was further confirmed by single crystal X-ray diffraction. These reactions indicate that the nitro group at position 5 of 1-methyl-4,5-dinitroimidazole is quite unstable, as well as partial substitution of nitro group at position 4 also occurred in aqueous ammonia. Only one nitro group of the two is involved in nucleophilic substitution reaction in each case.

This compound(1-Methyl-4-nitro-1H-imidazol-5-amine)Name: 1-Methyl-4-nitro-1H-imidazol-5-amine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optical rotation and atomic dimension, published in 1934, which mentions a compound: 616-14-8, mainly applied to , Name: 1-Iodo-2-methylbutane.

The 1-F, 1-Cl, 1-Br and 1-I derivatives of 2-methylbutane have [M]D20 -799.1°, 179.1°, 610.1° and 1124.7°, resp. If the F derivative is classified with the other halogen derivatives, the values for the ratio Cl-F, Br-Cl and I-Br are 41:18.1:21.6 which agree well with the ratios of the resp. at. diameters.

《Optical rotation and atomic dimension》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Name: 1-Iodo-2-methylbutane.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 616-14-8, is researched, Molecular C5H11I, about Synthetic methods and reactions. 63. Pyridinium poly(hydrogen fluoride) (30% pyridine-70% hydrogen fluoride): a convenient reagent for organic fluorination reactions, the main research direction is fluorination pyridinium polyhydrogen fluoride; diazotization fluorination; safety pyridinium polyhydrogen fluoride.SDS of cas: 616-14-8.

Pyridinium polyhydrogen fluoride (30% pyridine-70% HF) reagent, a stabilized, less-volatile form of HF, is a convenient and effective fluorinating agent. Fluorination, halofluorination, nitrofluorination, and hydrofluorination of olefins were achieved using the reagent. The in situ diazotization and subsequent fluorinative dediazonization of α-amino acids, aminoarenes, and carbamates yielded α-fluorocarboxylic acids, aryl fluorides, and fluoroformates, resp. Geminal dihalides and α-halo ketones were treated with HgO in pyridinium polyhydrogen fluoride to form geminal difluorides and α-fluoro ketones. Solutions of alkali halides in pyridinium polyhydrogen fluoride were also effective halogenating agents for aminoarenes, via in situ diazotization and subsequent nucleophilic dediazonization by the corresponding halides, as well as for alcs., via SN2 displacement reactions. Diazo ketones and diazoalkanes also reacted smoothly with halide ions in pyridinium polyhydrogen fluoride solution to give the corresponding geminally halofluorinated compounds Proper precautions must be observed in using pyridinium polyhydrogen fluoride.

《Synthetic methods and reactions. 63. Pyridinium poly(hydrogen fluoride) (30% pyridine-70% hydrogen fluoride): a convenient reagent for organic fluorination reactions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)SDS of cas: 616-14-8.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 616-14-8, is researched, SMILESS is CCC(CI)C, Molecular C5H11IJournal, Iranian Journal of Catalysis called Application of multipurpose dimethyl formamide-like task specific ionic liquid as a recyclable reagent for direct iodination of alcohols, Author is Hullio, Ahmed Ali; Mastoi, G. M., the main research direction is iminium chloride catalyst preparation green chem; alkyl aryl iodide preparation green; alc iminium chloride catalyst iodination green.Reference of 1-Iodo-2-methylbutane.

A direct and an efficient conversion of a wide range of primary, secondary and tertiary alcs. to the corresponding iodides was obtained under ionic liquid conditions. The method involves preparation of ionic liquid-based iminium chloride intermediate from DMF-like ionic liquid then stirring it with alc. in present of sodium iodide. The higher yields of alkyl iodides were obtained within min. time with simplest operational procedure and DMF-like ionic liquids could be recycled.

《Application of multipurpose dimethyl formamide-like task specific ionic liquid as a recyclable reagent for direct iodination of alcohols》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Reference of 1-Iodo-2-methylbutane.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Methyl-4-nitro-1H-imidazol-5-amine, is researched, Molecular C4H6N4O2, CAS is 4531-54-8, about A catalyst and additive-free three-component reaction of highly electrophilic azides with cyclic ketones and cycloaliphatic amines. Synthesis of novel N-heteroaryl amidines.Reference of 1-Methyl-4-nitro-1H-imidazol-5-amine.

Highly electrophilic 5-azido-1-methyl-4-nitro-1H-imidazole and sulfonyl azides were demonstrated to react with alicyclic amines and cyclic ketones in the absence of any catalyst or additive to afford novel N-(4-nitroimidazol-5-yl)- or N-sulfonylamidines resp. Based on single crystal X-ray anal., a revision of the previously reported data of Gao and co-workers on the direction of the reaction of sulfonyl azides with endocyclic enamines was made. The reaction of 2,6-diazidopyridine with an enamine, 4-(cyclohex-1-en-1-yl)morpholine, proceeded with cyclization of the azide moiety onto the pyridine C=N bond to form an amidine bearing the tetrazolo[1,5-a]pyridine fragment.

《A catalyst and additive-free three-component reaction of highly electrophilic azides with cyclic ketones and cycloaliphatic amines. Synthesis of novel N-heteroaryl amidines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Methyl-4-nitro-1H-imidazol-5-amine)Reference of 1-Methyl-4-nitro-1H-imidazol-5-amine.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optical rotation and atomic dimension》. Authors are Brauns, D. H..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Safety of 1-Iodo-2-methylbutane. Through the article, more information about this compound (cas:616-14-8) is conveyed.

This is a discussion (without new exptl. data) of a modified Guye’s law using the differences in at. dimensions, F-Cl, Cl-Br, and Br-I. B. tabulates the sp. and mol. rotations of the halogen compounds obtained by replacing the O-acetyl group of the 1st asym. C atom of acetyl sugars by F, Cl, Br, and I and for these and related compounds formulates 2 different rules: (1) when the halogen is attached directly to the asym. C atom the sp. rotations show differences proportional to the differences in at. dimensions, and (2) when the halogen is attached indirectly to the asym. C atom the mol. rotations show differences proportional to the differences in at. dimensions.

《Optical rotation and atomic dimension》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Safety of 1-Iodo-2-methylbutane.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optical rotation and atomic dimension》. Authors are Brauns, D. H..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Recommanded Product: 616-14-8. Through the article, more information about this compound (cas:616-14-8) is conveyed.

The 1-F, 1-Cl, 1-Br and 1-I derivatives of 2-methylbutane have [M]D20 -799.1°, 179.1°, 610.1° and 1124.7°, resp. If the F derivative is classified with the other halogen derivatives, the values for the ratio Cl-F, Br-Cl and I-Br are 41:18.1:21.6 which agree well with the ratios of the resp. at. diameters.

《Optical rotation and atomic dimension》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Recommanded Product: 616-14-8.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Electric Literature of C5H11I. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. Author is Hartmann, Rolf W.; Batzl, Christine.

Piperidinediones I (R = H, Me, Et, Pr, CHMe2, CH2CHMe2, CHMeEt, pentyl, isopentyl, CH2CHMeEt, sec-pentyl, hexyl, heptyl) were prepared by alkylating PhCH2CN, addition reaction of PhCHRCN with CH2:CHCN, hydrolysis and ring closure of NCCRPhCH2CH2CN, nitration, and reduction of the nitro group. In vitro I showed a stronger inhibition of human placental aromatase than aminoglutethimide (II). The most active derivative, I (R = isopentyl), showed a 93-fold stronger inhibition than II. I, except I (R = CHMe2, CH2CHMe2, CHMeEt) exhibited equal or lower inhibition of bovine adrenal desmolase than II. Many I showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin-primed rats than II. They inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene tumor-bearing rats more strongly than II. Being stronger and more selective inhibitors of the estrogen biosynthesis than II, some of the newly developed derivatives of II might be better candidates for the treatment of hormone-dependent human breast cancer.

《Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Electric Literature of C5H11I.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Synthetic methods and reactions. XIII. Preparation of alkyl halides from alcohols with alkali halides in polyhydrogen fluoride/pyridine solution, the main research direction is halide alkyl cycloalkyl adamantyl; benzyl halide; norbornyl halide.COA of Formula: C5H11I.

Thirty-nine RX (R = C4-8 alkyl, cyclopentyl, cyclohexyl, adamantyl, norbornyl, PhCH2; X = F, Cl, Br, I) were prepared by reaction of the corresponding ROH with MX (M = Na, K, NH4) in polyhydrogen fluoridepyridine. Thus, BuCH2OH was kept 1 hr with 70% HF-pyridine containing NaCl to give 89% BuCH2Cl.

《Synthetic methods and reactions. XIII. Preparation of alkyl halides from alcohols with alkali halides in polyhydrogen fluoride/pyridine solution》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)COA of Formula: C5H11I.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 1-Methyl-4-nitro-1H-imidazol-5-amine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Methyl-4-nitro-1H-imidazol-5-amine, is researched, Molecular C4H6N4O2, CAS is 4531-54-8, about Synthesis of imidazo[4,5-b]pyrazine nucleosides. Author is Panzica, Raymond P.; Townsend, Leroy B..

5,6-Dimethyl-1-(β-D-ribofuranosyl)imidazo[4,5-b]pyrazine (I; R = β-D-ribofuranosyl) was prepared by glycosylation of the Me3Si derivative (I; R = Me3Si) (II), by fusion with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose, or by cycloaddition of 4,5-diamino-1-(β-D-ribofuranosyl)-imidazole with biacetyl.

《Synthesis of imidazo[4,5-b]pyrazine nucleosides》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Methyl-4-nitro-1H-imidazol-5-amine)Application In Synthesis of 1-Methyl-4-nitro-1H-imidazol-5-amine.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem